Sulbutiamine (isobutyrylthiamine disulfide) is a lipophilic derivative of thiamine. It is available without a prescription in several countries, either as a component of dietary supplements or as a pharmaceutical drug. Arcalion (Sulbutiamine) is prescribed for the treatment of patients with various diseases such as asthenia, chronic fatigue, diabetes, hypothyroidism, kidney disease, fibromyalgia and depression (postpartum).
It addresses symptoms of weakness by increasing focus, strength (both physical and mental) and energy, making you more alert, less lethargic and more optimistic, and helping to stabilize your sleep patterns. In addition, this medicine can also help the patient's memory and strengthen thinking processes. Some patients even reported slight improvements in vision.
This product is also popular among athletes as a dietary supplement because it is a vitamin compound that will not show up on competitive sports blood tests. This can help you realize your maximum potential and replenish your energy after strenuous activities, allowing you to maintain your edge. Monitoring the presence of sulfutiamine in urine doping control samples to assess the relevance of its use in sport.
The motivational, confidence-boosting effects of sulfuthiamine are thought to be due to its ability to increase sensitivity to dopamine.
In animal models, sulfuthiamine has been shown to increase the number of dopamine binding sites (particularly D1) in the prefrontal cortex, an effect achieved by reducing dopamine release.
Sulfutiamine is best thought of as a dopamine modulator rather than a compound that directly inhibits or enhances dopamine release. In addition, sulfutiamine has been found to improve memory, possibly through cholinergic transmission.
Research shows that high-affinity choline uptake (HACU) was moderately increased in the brain of rodents after sulfutiamine consumption. However, it should be noted that the doses used were high (300 mg/kg).